Primary study on immunomodulatory effect of ursolic acid in mice
- VernacularTitle:熊果酸免疫调节作用的初步研究
- Author:
Yingjie FENG
;
Huixun REN
;
Yukang YUAN
;
Fei SHEN
;
Guixiang FAN
- Publication Type:Journal Article
- Keywords:
ursolic acid;
immunoregulation;
Th balance;
mice
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To confirm the immunomodulatory effect of ursolic acid on normal and immunosuppressive mice caused by cyclophosphamide.Methods We assayed the function of T lymphocyte transformation with MTT test,examined the function of B lymphocyte with hemolysis spectrophotography,determined the function of non-specific immunity with phagocytosis of macrophages,and measured the content changes of Th_(1) cytokine IL-2 and Th_(2) cytokine IL-6 in serum with ELISA.Results Ursolic acid had a suppressant effect on the function of humoral immunity and enhanced cell-mediated immune response at the low dosage but presented opposite effect at the high dosage in normal mice.Ursolic acid significantly improved immune function on immunosuppressive mice caused by cyclophosphamide(P
