The effect of curcumin on the expression of apoptosis-related genes Bcl-2 and Bax after cerebral ischemia in hippocampal CA1 and CA3 areas and its significance
- VernacularTitle:姜黄素对沙土鼠脑缺血再灌注后海马CA1区及CA3区Bcl-2、Bax表达的影响及意义
- Author:
Hong CAO
;
Jun LI
;
Guangming LI
;
Yaoqi WANG
;
Yinming ZENG
- Publication Type:Journal Article
- Keywords:
curcumin;
Bcl-2;
Bax;
gerbil;
hippocampus;
brain ischemia;
reperfusion
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of apoptosis-related genes Bcl-2 and Bax after cerebral ischemic reperfusion in hippocampal CA1 and CA3 areas and the effect of curcumin on the expression of Bcl-2 and Bax in gerbils.Methods Gerbils were randomly divided into sham group(SH),ischemia-reperfusion group(IR),curcumin group(CU) and solvent control group(SC).Forebrain ischemia was induced by occlusion of bilateral common carotid arteries.Observations were made in each group 1d,3d,5d and 7d after ischemia.Open field test was used to examine the behavioral change.The apoptotic neurons in hippocampal CA1 region was counted,and the expression of Bcl-2 and Bax in hippocampal CA1 and CA3 areas was detected by SABC immunocytochemical technique.Results The behavioral mark and the number of apoptotic neurons in hippocampal CA1 and CA3 areas were much smaller in CU group than in IR group(P
