The apoptotic chondrocytes in articular cartilage of children and adults with Kashin-Beck disease
- VernacularTitle:大骨节病儿童及成人关节软骨细胞凋亡特征的比较
- Author:
Shijie WANG
- Publication Type:Journal Article
- Keywords:
Kashin-Beck disease;
apoptosis;
Bcl-2;
Bax
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the different characteristics of chondrocyte apoptosis and the expression of(Bcl-2) and Bax in articular cartilage of children and adults with Kashin-Beck disease(KBD) so as to probe into the pathogenesis of chondronecrosis in KBD.Methods The collected samples of articular cartilage were divided into four groups: the control children(15 cases),KBD children(15 cases),the control adults(12 cases) and KBD adults(12 cases).Chondrocyte apoptosis was detected by the TUNEL method,and the Bcl-2 and Bax positive articular chondrocytes were stained by B-SA immunohistochemistry.Results ① The percentage of positive apoptotic chondrocytes stained by TUNEL in the middle zone of articular cartilage in the KBD-children group was higher than that in the control(P
