The evaluation of insulin resistance and ?-cell function in patients with systemic lupus erythematosus
- VernacularTitle:系统性红斑狼疮患者胰岛素抵抗情况和胰岛?细胞功能的评价
- Author:
Hui GUO
;
Yali ZHANG
;
Shumei WANG
;
Bingyin SHI
- Publication Type:Journal Article
- Keywords:
systemic lupus erythematosus;
insulin resistance;
islet ?-cell function;
fasting plasm glucose
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate insulin resistance and ?-cell function in patients with systemic lupus erythematosus(SLE).Methods The study group included thirty-two female SLE patients who were hospitalized or received outpatient treatment in our hospital;the control group consisted of twenty-two healthy females.Their fasting plasm glucose and serum insulin were all tested.Homeostasis model assessment(HOMA) was used to calculate HOMA-IR and HOMA-?-cell function,and these parameters were compared between the study group and control group.Results Compared with control group,the SLE patients had significantly higher fasting insulin levels(12.13?4.32 vs.8.84?2.19,P0.05).Conclusion Patients with SLE have a higher risk of insulin resistance and abnormal insulin secretion than controls.
