Effects of resveratrol on apoptosis of intestinal mucosal cells in rats with severe acute pancreatitis
- VernacularTitle:白藜芦醇对大鼠重症急性胰腺炎肠黏膜细胞凋亡的影响
- Author:
Huanchen SHA
;
Qingyong MA
;
Liancai WANG
- Publication Type:Journal Article
- Keywords:
severe acute pancreatitis;
resveratrol;
apoptosis;
bax protein
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of resvertrol on apoptosis and the expression of apoptosis-regulated genes Bax in rats with experimental severe acute pancreatisis.Methods Totally 54 SD rats were randomly divided into 3 groups: sham-operation group(SO),severe acute pancreatitis group(SAP),and resveratrol-treated group(RES).In SO group the pancreases were slightly flipped only.The SAP model was set up by giving 40g/L sodium chrolate(1mL/kg) through pancreatic duct,and resveratrol(5mg/mL,10mg/kg) was given intravenously.Apoptosis of mucosal cells was detected by TUNEL methods,and the expression of Bax protein was determined by SP immunohistochemical technique.Results The apoptotic index of mucosal cells in SAP group at 3,6 and 12 hours after induction of severe acute pancreatitis was significantly higher than that in resveratrol-treated group((P
