Clinical observation of cardiotoxicity induced by radiotherapy and chemotherapy in patients with breast cancer
- VernacularTitle:联合放化疗对乳腺癌患者心脏毒性的临床观察
- Author:
Qian TONG
- Publication Type:Journal Article
- Keywords:
Cardiotoxicity;
Radiotherapy;
Chemotherapy;
Breast cancer
- From:
Cancer Research and Clinic
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the cardiotoxicity during combined radiotherapy and chemotherapy or chemotherapy alone in patients with breast cancer. Methods Sixty-eight patients received epirubicin or combined with radiotherapy postoperative were observed. Electrocardiogram was examined before and after each cycle of chemotherapy. The results were tested statistical comparison. Results The cardiotoxicity in breast cancer patients who were treated with both radiotherapy and chemotherapy are obviously higher than that with chemotherapy alone. The incidence of abnormal electrocardiogram in combination group was 36.8 % and 10 % in non-combination group, and with no statistical difference between the two groups. Conclusion The cardiotoxicity increased more in breast cancer patients who were treated with both radiotherapy and chemotherapy. Our results suggested that breast cancer patients should be regularly reexamined with electrocardiogram during therapy, especially whose were above 60 years and those had the history of hypertension and heart diseases.
