Expression and clinical significance of p16 and p27kip1 in endometrial carcinoma
- VernacularTitle:子宫内膜癌组织中基因p16和p27kip1的表达及其临床意义
- Author:
Jinping XU
;
Yun ZHANG
- Publication Type:Journal Article
- Keywords:
p16;
p27kip1;
Endometrial carcinoma
- From:
Cancer Research and Clinic
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression and clinical significance of p16 and p27kip1 in endometrial carcinoma. Methods 65 cases of endometrial carcinoma were examined by immunohistochemical method for p16 and p27kip1. Results The positive rates of p16 and p27kip1 was 47.7 % and 41.5 % respectively. Both the expression of p16 and the expression of p27kip1 were correlated with histologic differentiation. Conclusions p16 and p27kip1 may play important roles in the development of endometrial carcinoma. They were important in predicting the prognosis and directing the treatment of endometrial carcinoma.
