Costimulatory molecules and allograft rejection
- VernacularTitle:协同刺激因子与器官移植排斥
- Author:
Fang YE
;
Zhenhua QIAO
- Publication Type:Journal Article
- Keywords:
Costimulatory molecules;
Allograft rejection
- From:
Cancer Research and Clinic
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Allograft rejection after xero organ transplantation rejection, especially acute rejection is still the major reason of failure and death. Active T cell play key roles in allograft rejection. It has been showed that the expressions of costimulatory molecules are associated with xero organ transplantation rejection. The pathways of CD28/CTLA-4 and CD40/CD40L are important costimulatory pathways that cause T cell activation.The article emphasizes on the role of CD28/CTLA-4-B7 pathway in allograft rejection.
