Simvastatin effect on inhibiting of the production of serum IL-6 and promotion the regeneration of sciatic nerve of rats
- VernacularTitle:Simvastatin抑制白介素-6的产生促进大鼠坐骨神经再生
- Author:
Zhi ZHAO
;
Hui ZHAO
;
Shuhong LU
- Publication Type:Journal Article
- Keywords:
simvastatin;
sciatic nerve regeneration;
CMAP;
IL-6;
TNF-?
- From:
Orthopedic Journal of China
2006;0(24):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To study the effect of Simvastatin on the regeneration of sciatic nerve of rats and its mechanism of immunoregulation.[Method]Twenty eight female Sprague-Dawley rats were used and the rats experienced the sciatic nerve crush injury.Animals were randomized into: Simvastatin-treated crush injury animals,vehicle-treated crush injury animals and sham-operated animals.Simvastatin(20 mg/kg) was given once a day over a time period of 14 day sby oral gavage via a pharyngeal tube.After surgery,the functional evaluation of nerve recovery,electrophysiologic assessment,histological assessment,serum IL-6 and TNF-? assessment were performed.[Result]The toe spread index of Simvastatin-treated crush injury animals was higher significantly than that of vehicle rats at d5 and d8(P
