Inhibition effects of complement depletion with CVF on cardiac allografts rejection in inbred strain rats
- VernacularTitle:眼镜蛇毒因子消耗补体对大鼠移植心急性排斥反应的抑制作用
- Author:
Gang LAN
;
Kang YANG
;
Yun BAI
- Publication Type:Journal Article
- Keywords:
Direct lytic factors;
Complement;
Heart transplantation;
Graft rejection
- From:
Chinese Journal of Organ Transplantation
2005;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the efficacy of complement depletion with CVF in preventing a-cute rejection after heart allotransplantation in inbred strain rats. Methods Inbred male Lewis rats were used as recipients and Brown-Norway rats as donors, and the heterotopic heart transplantation model was established. The allografts were divided into 2 groups (n=8 in each group). After infusing low-dose CVF 20?g/kg to the CVF-treated group, cardiac allograft survival time was observed on 4 rats of each group. The remaining 4 rats in each group were killed respectively at day 1,3,5 and 6, the pathological grade for acute rejection, the complement activity in serum, the deposition of C3 on tissue, and the extent of infiltration by CD3+ T cells were compared. Results The mean survival time of heart allograft was (11. 69?0. 72) days and (6. 65?0. 35) days in CVF-treated group and control group respectively (P
