Evaluation of tumor drug resistance with Ku80 mRNA expression in human lung cancer
- VernacularTitle:人非小细胞肺癌组织中Ku80 mRNA表达评价化学治疗敏感性的研究
- Author:
Jie ZHANG
;
Xiaowen ZHENG
;
Mingyu XU
;
Zhenzhong SU
;
Yue ZHI
;
Baorong CHI
- Publication Type:Journal Article
- Keywords:
Lung cancer;
Ku80 mRNA expression;
Chemotherapy
- From:
Chinese Journal of Immunology
1999;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the different Ku80 mRNA expression in normal lung tissue group, lung cancer group(non small cell lung cancer) without chemotherapy, lung cancer group with multiple chemotherapy(n≥2),to evaluate the relationship of tumor drug resistance with Ku80 mRNA expression in human lung cancer.Methods:The lung tissue gene level of Ku80 mRNA was measured by reverse transcription polymerase chain reaction(RT-PCR) in 25 normal lung tissues, 51 lung cancer tissue,taking ?-actin as inner reference.The data were analyzed by SPSS software.Results:Ku80 mRNA expression in normal lung tissue compared to lung cancer group without chemotherapy, lung cancer group with multiple chemotherapy(n≥2) had statistic significant meaning,respectively P
