Study on memory T cell subsets in peripheral blood of patients with multiple sclerosis
- VernacularTitle:多发性硬化患者外周血记忆性T细胞亚群的研究
- Author:
Guangzhi LIU
;
Xuguang GAO
- Publication Type:Journal Article
- Keywords:
Memory T cell subset;
Multiple sclerosis;
IL-15;
Peripheral blood;
CCR7
- From:
Chinese Journal of Immunology
1999;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explored the mechanisms that lead to the changes of the memory T cell subsets.Methods:By using of flow cytometry and enzyme-linked immunosorbent assay(ELISA), we detected the percentage of memory T cell subsets and plasma concentration of interleukin-15(IL-15) in peripheral blood of MS patients and healthy individuals. Furthermore, MS patients were subdivided into both relapse-remission MS(RRMS) and chronic progressive MS(CPMS) group according to the clinical features.Results:Compared to healthy controls, there was an increase and decrease in CD8~+T_ CM and terminal effector memory CD8~+T cell in MS patients(P
