Experimental observation of the changes and correlation of bone collagen and biomechanical property in osteoporosis rats
- VernacularTitle:骨胶原在骨质疏松大鼠中的变化及其与骨生物力学相关性实验研究
- Author:
Jianfeng ZHANG
;
Yunzhen CHEN
;
Haichun LIU
- Publication Type:Journal Article
- Keywords:
osteoporosis;
bone collagen;
biomechanism;
rats
- From:
Orthopedic Journal of China
2006;0(23):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To investigate the changes and correlation of bone collagen and biomechanical property in osteoporosis rats.[Method]Normal 30 nullimating female 7 month SD rats were divided randomly to two groups,each included 15.The sham group was unovariectomized,and the OVX group was ovariectomized.To execute the rats after 12 weeks,the author get the 5th lumbar vertebra,and then detected the biomechanical property and HYP.The author observed the collagen morphology of the 4th lumbar vertebra using the microscope after the masson triad color dyeing.[Result]Twelve weeks later,HYP in the sham group was(0.197?0.035)mg/g.The bone collagen was regular,compact,and closed succession.HYP in the OVX group was(0.182?0.022)mg/g.The bone collagen was incompact,thin,collapse and poor succession.There was significant change of the HYP in two groups(P
