Expression of apoptosis inhibision protein, Survivin,P53,and HPV in cervical carcinomas
- VernacularTitle:Survivin在宫颈鳞癌组织中的表达及其与p53基因表达及HPV感染相关性
- Author:
Jingping CHU
;
Yankui WANG
- Publication Type:Journal Article
- Keywords:
Genes;
Genes,survivin;
Genes,p53;
Cervixneoplasms;
Immunohischemistry
- From:
China Oncology
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose:Survivin,a member of the inhibiter of apoptosis gene family,has been detected in fetal tissue and in variety of human malignancies.In the current study,we not only investigated the expression of a novel inhibitor gene of apoptosis,survivin in Cervixneoplasms but also studied its relationship between the expression of P53 and HPV-16. Methods:Using streptavidin-bintin peroxidase(SP)method,We examinined the expression of the proteins survivin , p53 and HPV-16 in 21 normal cervical tissues ,33 CIN and 72 cervical cacinoma tissues.Results:Survivin was expressed in 52 of 72(72.2%) cases of cervical carcimomas ,however,it was not expressed in normal cervical tissues and it was expressed in6 of 33(18.18%)cases of CIN. Overexpression of survivn was related to the tumor grade and clinical stage.Survivin positive cases were strongly associated with p53 expression (P
