Methylation of gene promoter and chemorisistance
- VernacularTitle:基因启动子甲基化和化疗耐药
- Author:
Yang CAI
;
Xinmiao YANG
;
Xichun HU
- Publication Type:Journal Article
- Keywords:
promoter;
methylation;
chemoresistance
- From:
China Oncology
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Mutation, translocation and loss of some genes have been known to contribute to chemoresistance, epigenetic mechanisms may also play an important role. About 29 000 CpG islands are primarily distributed in the promoter and the first exon regions of protein coding genes in normal cells. However, cancer cells exhibit significant changes in terms of DNA methylation, which can be summarized as global hypomethylation of the genome accompanied by focal hypermethylation. The relationship between aberrant methylation of gene in the promoter and chemoresistance was discussed in the review. A brief summary was also introduced with regard to the advances how in reversing aberrant methylation and overcoming chemoresistance.
