The relationship between COX-2 and Ki-67 proliferation index, bax, microvascular density and CD_(44v6) in cervical carcinoma
- VernacularTitle:子宫颈癌中环氧化酶-2与Ki-67增生指数、bax、微血管密度以及CD_(44v6)关系的研究
- Author:
Huiling BI
;
Quanhong WANG
;
Xiuzhu TIAN
- Publication Type:Journal Article
- Keywords:
COX-2;
Ki-67;
bax;
Microvascular density;
CD_(44v6);
Cervical carcinoma
- From:
Cancer Research and Clinic
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between COX-2 and Ki-67 proliferation index, bax, microvascular density(MVD)and CD44v6 respectively. Methods The expression of COX-2,Ki-67, bax, MVD (labelled by CD34) and CD44v6 were examined by immunohistochemistry PV method and tissue chip method in 101 cases of cervical carcinomas epithelium. Results The expression of COX-2 in cervical carcinomas has positive correlation with Ki-67, MVD and CD44v6, but has no correlation with bax. Conclusion The probable mechanisms are related with neovascularization, cell proliferation and cell adherence, but not related with the expression of bax.
