Fetal karyotyping by color Doppler ultrasound-guided percutaneous umbilical blood sampling with fetuses cardiac anomalies
- VernacularTitle:超声引导脐静脉穿刺取血研究胎儿先天性心脏异常的染色体核型
- Author:
Hong WANG
;
Danming GENG
;
Xuejun TU
;
Xiangdong TU
;
Baozhen ZHANG
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Umbilical veins;
Cordocentesis;
Chromosome aberrations;
Heart defects,congenital
- From:Chinese Journal of Ultrasonography
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To perform fetal karyotyping by percutaneous umbilical blood sampling guided by color Doppler ultrasonography in fetuses with congenital cardiac anomalies. Methods Fetal blood samples obtained by color Doppler ultrasound-guided cordocentesis in 56 fetuses with cardiac abnormalities detected by fetal echocardiography were taken for karyotyping.Fetuses were monitored post operation. Results The procedures were successfully performed in all cases and no procedure-related complications occurred.Six cases with abnormal karyotypes, 1 trisomy 21,2 trisomy 18,1 trisomy 13,1 trisomy AO and 1 cases 47XYY were identified and pre-operation ultrasonography detected multiple system anomalies besides cardiac anomalies in them. Conclusions Color Doppler ultrasonography facilitated percutaneous umbilical blood sampling by clear umbilical vein imaging and shortening the operation time.Abnormal karyotypes in fetuses with cardiac anomalies seemed to be related with multiple system anomalies.
