Effects of Celecoxib on Proliferation of Human Colonic Cancer Cells and on The Hepatic Metastasis of Animal Model
- VernacularTitle:塞来昔布对人结肠癌细胞生长及裸鼠肝转移瘤形成的影响
- Author:
Wei LIU
;
Jie AN
;
Chao ZHANG
;
Zhankui LIU
- Publication Type:Journal Article
- Keywords:
Colonic neoplasm Cyclooxygenase Celecoxib
- From:
Chinese Journal of Bases and Clinics in General Surgery
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the potential roles of celecoxib on proliferation and cell cycle progression of colon adenocarcinoma cells and on the hepatic metastasis of nude mice. Methods The human colon cancer cells HT-29 and HCT-116 were employed in the study. After treatment with celecoxib, the inhibitory effects of celecoxib on the proliferation of cancer cells were quantified by MTT assay, and the cell cycle progression was detected by flow cytometry, tumor cells were inoculated in nude mice, and the hepatic metastasis was detected. Results ①Celecoxib inhibited the proliferation of the tumor cells in time and dose-dependent manners (P
