Discussion on Mechanism and Effect of Mica Granules on Rats' Stomach Mucosa Injury Induced by Non-water Ethanol
- VernacularTitle:云母颗粒对无水乙醇诱导大鼠胃黏膜损伤的影响及机理探讨
- Author:
Danping QIAN
;
Haili LV
;
Guomin SHAO
- Publication Type:Journal Article
- Keywords:
mica granules;
non-water ethanol;
injury index;
injury degree;
SOD;
MDA;
GSH-Px
- From:
Journal of Zhejiang Chinese Medical University
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To study the protection and mechanism of mica granules to rats stomach mucosa injury caused by non-water ethanol.[Method] Randomly divide 48 healthy SD rats into high-,middle-and low-dosed groups of mica granules,Simida group,model control group and blank control group as well,i.e.6 groups.After fasting for 24h,separately make stomach perfusion of mica granules and Simida to all rats in advance;after 3h,make stomach perfusion of non-water ethanol 1ml/100g for stomach mucosa injury;45m later,take proper blood of lower vena cava,sacrifice them for stomach,then respectively test all mucosa injury index,SOD,MDA,and GSH-Px content in serum and mucosa,observe pathological changes to evaluate mucosa injury degree and medical function.[Result] In mica groups,the SOD and GSH-Px were markedly higher than that in model control group,but MDA was lower than later(P
