Effect of CYP2A6 genetic polymorphisms on serum concentration of sodium valproate
- VernacularTitle:CYP2A6基因多态性对丙戊酸钠血药浓度的影响
- Author:
Yanping SUN
;
Lan TAN
;
Jinghui SONG
- Publication Type:Journal Article
- Keywords:
Aryt hydorcarbon hydroxylases;
Mixed function oxygenases;
Polymorphism(genetics);
Valproic Acid;
Pharmacokine tics
- From:
Chinese Journal of Neurology
2005;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of cytochrome P_ 450 2A6 (CYP2A6) genetic polymorphisms on serum concentration of sodium valproate. Methods A total of 98 epileptic patients receiving sodium valproate after a period of more than 5 half-time were recruited. The genotypes of CYP2A6 of the patients were detected by nested-primer polymerase chain reaction (PCR) to examine the alleles CYP2A6*1 and CYP2A6*4. Fluorescence polarization immunoassay (FPIA) was used to measure the serum concentration of sodium valproate. Results Of the 98 cases, 73 (74.5%) were wild genotypes, 24 (24.5%) were CYP2A6*1/*4 genotypes and 1(1.0%) was CYP2A6*4/*4 genotype. According to the genotypes of CYP2A6 the patients were divided into two groups,one was group A (CYP2A6*1/*1) and the other was group B (CYP2A6*1/*4 or *4/*4). The mean value of the serum concentration of sodium valproate of the patients in group A(4.1393?0.2793) was higher than that in group B(3.3486?0.3919) with a statistical significance (P
