Relation between the osteolysis and inducible nitric oxide synthase peroxynitrite around failed hip protheses
- VernacularTitle:镁硅玉人工髋关节假体周围骨溶解与诱导型一氧化氮合酶、过氧亚硝基阴离子的关系
- Author:
Tao CHENG
;
Ming DAI
;
Liang HAO
- Publication Type:Journal Article
- Keywords:
osteolysis;
artificial hip prostheses;
inducible nitric oxide synthase;
peroxynitrite anion
- From:
Orthopedic Journal of China
2006;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To observe expression of inducible nitric oxide synthase and peroxynitrite anion around the prostheses,and study the relationship between the osteolysis and inducible nitric oxide synthase peroxyni-trite.[Method]Interface tissues were obtained at three Delee-Charnley acetabular sections and seven Gruen femur sections in six revision total hip arthroplasty surgery. The tissues were prepared for immunohistochemical assays to determine the expression of iNOS and nit rotyrosine (NT)-a specific“footprint”of peroxynitrite. Pre-revision X-ray films were observed to determine the incidence of osteolysis regions and non-osteolysis regions. The correlation between the positive cells and the severity of osteolysis were analyzed and compared.[Result]Data showed that zone Ⅲ has much higher iNOS positive immunostaining than that of zone Ⅰ and Ⅱ at acetabulum, and the expression of zone 1、2、6、7 was significantly higher than the other zone at femur(P
