Different doses of vitamin K3 effect the expression of OPN of rats kidney
- VernacularTitle:不同剂量维生素K_3对大鼠肾骨桥蛋白表达的影响
- Author:
Guohai SHI
;
Wenfeng LI
;
Shiqing ZHANG
- Publication Type:Journal Article
- Keywords:
Vitamin K3;
Renal calculus;
Osteopontin(OPN)
- From:
Chinese Journal of Urology
2006;0(S2):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of different doses of Vitamin K3 on the expression of osteopontin in rats kidney. Methods After different dose of Vitamin K3 were injected to different groups of rats feeded with same stone-inducing agent, the level of expression of OPN in renal tissues was observed with immunohistological staining. Results OPN expression located at distal convoluted tubule when the rats feeded without stone-inducing agent, and the OPN expression stain was extended to proximal convoluted tubule when the stone-inducing agent was feeded. Vitamin K3 can decrease the extension of OPN expression induced by the agent and more doses of Vitamin K3, more effects. Conclusions Vitamin K3 can decrease the expression of OPN in the kidney tubule of rats feeded with stone-induced agent.
