Experimental study of nifedipine inhibitory effect on calcium oxalate crystallization in rats
- VernacularTitle:钙拮抗剂抑制大鼠肾草酸钙结石生成的实验研究
- Author:
Shiqing ZHANG
;
Wenfeng LI
;
Xing GU
- Publication Type:Journal Article
- Keywords:
Kidney calculi;
Calcium oxalate;
Nifedipine;
Free radical;
Apoptosis
- From:
Chinese Journal of Urology
2006;0(S2):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the effect of nifedipine on the formation of nephrolithiasis in rat models and its mechanism of action. Methods A total of 60 male Sprague-Dawley rats (body weight, 200-250g) were randomly divided into 6 groups, ie, control group, only nifedipine group, stone forming group, stone forming plus 3, 6, 10 mg?kg-1?d-1 nifedipine group. Each group is 10 rats respectively. Hyperoxaluria and calcium oxalate crystals were produced in rats by ethylene glycol in drinking water. Four weeks later, all rats were sacrificed and the calcium oxalate crystallization in kidney, the renal free radical level, the renal cell apoptosis indexes and the blood and urine biochemical indexes were detected. Results The renal calcium oxalate crystallization in the rat with different dose nifedipine was less than the stone forming rats 37.0%, 55.6%, 66.7% significantly (P
