Expression and significance of hepatocyte growth factor and c-Met in bladder transitional cell carcinoma
- VernacularTitle:肝细胞生长因子及其受体在膀胱癌中的表达及意义
- Author:
Hongguang JIANG
;
Xun HUANG
;
Luoyan YANG
- Publication Type:Journal Article
- Keywords:
Bladder transitional cell carcinoma;
Hepatocyte growth factor;
Immunohistochemistry
- From:
Chinese Journal of Urology
2006;0(S2):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the expression of hepatocyte growth factor and its receptor c-met in bladder transitional cell carcinoma, and to investigate correlations of the expression and clinic features of the tumor. Methods Samples of 45 human bladder carcinoma and 8 normal bladder tissues were detected with immunohistochemical method for HGF and c-met ,then relationships between the expressions and clinic features of the tumor were analyzed. Results There was no HGF expression and only 1 weak positive c-met expression in the normal urinary bladder tissues. While in bladde cancer specimens, positive expression rates of HGF and c-met were as high as 64.4%,62.2%, respectively.Coexpression rate of HGF and c-met was 42.2%. The positive rates were significantly higher in BTCC specimens than in normal tissues (P
