Establishment of transplantable rat prostate carcinomas and study of its relationship to hormone dependency
- VernacularTitle:种植性雄激素非依赖型前列腺癌动物模型的建立
- Author:
Lin CUI
;
Zhichen GUAN
- Publication Type:Journal Article
- Keywords:
Prostatic neoplasms;
Carcinoma;
Transplantable;
Nude mouse;
Testosterone
- From:
Chinese Journal of Urology
2006;0(S2):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish transplantable rat prostate carcinoma and study its relationship to hormone dependency. Methods Six transplantable rat prostate carcinoma lines were established from primary tumors developing in the dorsolateral prostate of F344 rats receiving a combined treatment with 3, 2’-dimethyl-4-aminobiphenyl (DMAB) and testosterone propionate (TP). Results Growth in the subcutis of nude mice (ICR-nu/nu) is rapid with a doubling time of approximately 10 days and transplantability is 100%. The histological appearance of the transplanted tumors is very similar to that of the primaries and their structures have not been altered by after 8 passages. Androgen receptor immunohistochemistry revealed all to be negative. Conclusions These data indicate that the model should prove useful for studies of invasion, metastasis, and hormone dependency of prostate carcinomas.
