Expression and significance of ezrin in human primary sporadic colorectal carcinoma
- VernacularTitle:Ezrin在散发性结直肠癌中的表达及意义
- Author:
Ge YAN
;
Xiaoyan ZHOU
;
Xiuying XIAO
;
Hongfen LU
;
Xiang DU
- Publication Type:Journal Article
- Keywords:
sporadic colorectal carcinoma(SCRC);
metastasis;
Ezrin;
immunohistochemistry
- From:China Oncology
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose:The membrane cytoskeletal crosslinker—Ezrin may be involved in several functions including cell adhesion,motility and cell survival.There is increasing evidence that it regulates tumor progression.However,the role of Ezrin in the carcinogenesis,progression and metastasis of primary sporadic colorectal carcinoma is still under investigation.This research is to study the expression,the localization and the clinical significance of Ezrin in human sporadic colorectal carcinoma(SCRC).Methods:Immunohistological EnVision staining was used to detect the expression of Ezrin in 132 cases of human sporadic colorectal carcinoma and 43 adjacent normal colorectal mucosa,and the different expressions of Ezrin among metastatic and non-metastatic SCRC,including 74 metastatic cases and 58 non-metastatic cases were also under investigation.Results:① The expression rate of Ezrin in SCRC was significantly higher than that in adjacent normal colorectal mucosa(79.5% Vs 11.6%,P
