The effect of lipoxygenase inhibitor (NDGA) on the expression of VEGF and CD44V6 in breast cancer MCF-7 cells
- VernacularTitle:脂氧合酶抑制剂NDGA对乳腺癌MCF-7细胞VEGF和CD44V6表达影响的研究
- Author:
Huantao LIU
;
Lubing TANG
- Publication Type:Journal Article
- Keywords:
Breast neoplasms?Lipoxygenase inhibitors?CD44V6?VEGF
- From:
Chinese Journal of Current Advances in General Surgery
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effects of VEGF and CD44V6 on breast cancer MCF-7 cells by NDGA.Methods:MCF-7 cells in the logarithmic growth state were selected and measured.There were four cell groups(concentration:0,1,10,100?mol/L)in the experiment.After 48h treatment of NDGA,the expression of VEGFmRNA was measured by RT-PCR and the expression of CD44V6 was examined by flow cytometry.Results:After treatment of NDGA,the expressions of VEGFmRNA and CD44V6 in NDGA groups were significantly lower than that of the control group(F=2996.13,P
