The preventive effect of nabumetone in the model of reflux esophagitis
- VernacularTitle:萘丁美酮在混合反流模型干预治疗中的作用
- Author:
Tao WANG
;
Jun GONG
- Publication Type:Journal Article
- Keywords:
nabumetone;
reflux esophagitis;
Barrett's esophagus;
esophageal adenocacinoma;
cyclooxygenase-2;
proliferating cell nuclear antigen;
Cyclin D_1
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the preventive effect of nabumetone on the damaged esophageal mucosa in the model of reflux esophagitis, and the effect of expression of cyclooxygenase-2(COX-2), proliferating cell nuclear antigen(PCNA), cyclin D_ 1 (CD_ 1 ) on the progress of reflux esophagitis. Methods A total of 100 SD rats were divided into three groups in random: group Y: operation + saline as positive controls(46); group R: operation + nabumetone(46); and group C: normal control(8). The lesions of esophageal mucosa were observed in the 5th, 17th, 28th , 40th week in groups Y and R and 40th week in group C, respectively. The change of COX-2, PCNA, and CD_ 1 by immunoperoxidase staining in the progress of reflux esophagitis(RE) and the effect of nabumetone were evaluated. Results The lesions of esophageal mucosa at different time and the incidence of Barrett's esophagus(BE) in group R were lower than those in group Y (P
