Influence of Astragalus and Thoroughfare Oral Liquid on immunological functions of immunosuppressive mice induced by hydrocortisone
- VernacularTitle:黄芪蛰虫口服液对氢化可的松免疫抑制小鼠免疫功能的调节作用
- Author:
Chunlan HOU
;
Lei DONG
;
Xinya ZHANG
;
Xiaohui WANG
- Publication Type:Journal Article
- Keywords:
Astragalus and Thoroughfare Oral Liquid;
immunological function;
hydrocortisone
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of Astragalus and Thoroughfare Oral Liquid(ATOL) on the immunological functions of the immunosuppressive mice induced by hydrocortisone (HC). Methods A total of 50 mice were divided into 5 groups randomly. Mice in 4 groups were immunosuppressive animal model induced by HC, then ATOL (0.2, 0.1 and 0.05mL/10g) was administered to 3 groups of them. The phagocytotic function of peritoneal macrophage, the proliferation rate of T cells in spleen, and the cytotoxicity of NK cells in spleen, and the production of antibodies and IL-2 by spleen cells were examined to evaluate the immunological function of mice. Results Different doses of ATOL could improve the phagocytotic function of peritoneal macrophage, the proliferation rate of T cells in spleen and the cytotoxicity of NK cells. The drug could also promote antibody formation as well as IL-2 in the immunosuppressive mice. Conclusion ATOL can evidently improve some of the immunological functions in HC-induced immunosuppressive mice.
