The relationship of interleukin-4 and interferon-? with steroid effect in children with primary nephrotic syndrome
- VernacularTitle:原发性肾病综合征患儿白细胞介素-4、?-干扰素与激素疗效的关系
- Author:
Huiping WANG
;
Changhong YANG
;
Yunying MAO
- Publication Type:Journal Article
- Keywords:
interleukin-4;
interferon-?;
primary nephrotic syndrome;
steroid effect
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between the activity of interleukin-4 and interferon-? with steroid effect in children with primary nephrotic syndrome before initiation of steroid therapy. Methods The activity of interleukin-4 and interferon-? in the supernatants of monocytes cell cultures activated with phytohemagglutinin was assessed with enzyme-linked immunosorbentassay in 31 children with primary nephrotic syndrome before iniatiation of steroid therapy. After steroid treatment for 8 weeks, data of steroid sensitivity and resistance were analyzed. Results Before initiation of steroid treament, in steroid sensitivity children with primary nephrotic syndrome an increased proliferative response of interleukin-4 was found (P0.05). Conclusion The activity of interleukin-4 is a useful tool for evaluating the likelihood of steroid sensitivity in children with primary nephrotic syndrome.
