Expression of oncogene c-met mRNA in nasopharyngeal carcinoma and its significance
- VernacularTitle:肝细胞生长因子受体原癌基因c-met mRNA在鼻咽癌中的表达及意义
- Author:
Chongmei LIU
;
Zhiming LIU
;
Minghui LIN
;
Min MAO
;
Jie WANG
- Publication Type:Journal Article
- Keywords:
Oncogene;
c-met mRNA;
Nasopharyngeal carcinoma
- From:
Cancer Research and Clinic
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of c-met mRNA in nasopharyngeal carcinomas(NPC) and its relation with clinical biological behavior. Methods In situ hybridisation was used to detect mRNA expression of c-met in 15 cases NP and 55cases NPC. Results The positive rate of c-met mRNA in NP and NPC cells were were 13.3 %(2/15) and 61.8 %(34/55) respectively. The expression of c-met mRNA was significantly correlated with lymphnode metastasis, local invasion(basilar destroying) (P 0.05). Conclusions The abnormality expression of c-met gene expression was well correlated with the biological behavior of metastasis and invasion. The expression of c-met mRNA could serve as an important index to estimate the prognosis of NPC. c-met may be a new diagnostic/therapeutic targert of NPC.
