Effect of mRNA expression of COX-2 and MMP-2 on the invasion and metastasis of bladder cancer and their correlation
- VernacularTitle:环氧化酶-2及基质金属蛋白酶-2mRNA的表达在膀胱癌浸润及转移中的作用及相关性
- Author:
Hepeng ZHANG
;
Dianjun GAO
;
Lianjun PAN
;
Xiyou WANG
- Publication Type:Journal Article
- Keywords:
mRNA expression;
COX-2;
MMP-2;
Invasion;
Metastasis;
Bladder cancer
- From:
Cancer Research and Clinic
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the mRNA expression of COX-2 and MMP-2 on transitional cell carcinoma of bladder(TCCB) and their relationship with the invasion and metastasis of the bladder neoplasm. Methods Surgical bladder specimens were obtained from 54 TCCB patients and 5 benign prostate hyperplasia (BPH) patients to make paraffin slices, and 8 specimens which against cancers. In situ hybridization (ISH) was used to assay the mRNA expression of COX-2 and MMP-2. Results The mRNA expression of COX-2 and MMP-2 in bladder neoplasm were 59.2 % and 57.4 % respectively. Compared to the control, their expression was higher (P
