The role of a single nucleotide polymorphism in MMP-1 and MMP-3 in carcinoma
- VernacularTitle:基质金属蛋白酶-1,3的单核苷酸多态性现象在癌症中的作用
- Author:
Haiqiong HAN
;
Shuli SHAO
- Publication Type:Journal Article
- Keywords:
Single nucleotide polymorphism;
MMP-1;
MMP-3;
Tumour invasion;
Metastasis
- From:
Cancer Research and Clinic
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Matrix Metalloproteinases is one of the critical enzymes that produce great influence during tumour invasion and metastasis. Single nucleotide polymorphism is single basic group changed at chromosome DNA sequence in certain site. MMP-1 promotor gene additional inserts guanopterin G at site -1607bp. In the tumor crowd, 2G homozygote has higher proportion. MMP-3 promoter region has a single adenine mononucleotide polymorphism site at -1171bp. MMP-3 5A genetype may increase the risk of lymphatic metastasis and have certain correlation with susceptibility
