Gray-scale contrast enhancement ultrasonography in rabbit liver and VX_2 tumor
- VernacularTitle:灰阶超声造影对正常肝实质及VX_2肿瘤血流动力学的对照研究
- Author:
Jie LI
;
Shaoping LIU
;
Qingzhao FU
;
Zhe MA
;
Guowei TAO
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Contrast media;
Liver neoplasms,experimental
- From:
Chinese Journal of Ultrasonography
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the hemodynamic features of VX_2 tumor and peri-neoplastic liver parenchyma with low mechanical index gray-scale contrast enhancement.Methods Ultrasound contrast agent SonoVue((0.1) ml/kg) was applied respectively in 8 VX_2-bearing rabbits by intravenous bolus injection.Corresponding parameters of the time-intensity curve:time to enhancement(ET),time to peak intensity(PIT),peak signal intensity(PSI) and mean transit time(MTT) were measured using low mechanical index contrast gray-scale imaging and Wash-in/Wash-out time-intensity curve software.Results Gray-scale imaging delineated clearly the dynamic enhancement of the VX_2 tumor and the surrounding liver parenchyma.The ET and PIT were definitely earlier,the PSI lower and the MTT absolutely shorter in VX_2 tumors than those in the liver parenchyma.There were significant differences of parameters derived from the time-intensity curve between VX_2 tumors and liver parenchyma(P
