Overexpression of extracelluar signal regulated protein kinase in the temporal lobe of human drug-resistant epilepsy
- VernacularTitle:细胞外信号传导激酶在耐药性颞叶癫患者中的表达
- Author:
Zhiqin XI
;
Xuefeng WANG
;
Yuan WU
;
Jijun SUN
;
Xi ZHU
;
Fei XIAO
;
Jinmei LI
;
Lifeng GUAN
;
Yun GONG
;
Fengying LIU
;
Yong YAN
;
Zhenli GUO
;
Guoming LUAN
;
Jianguo ZHANG
;
Yuping WANG
- Publication Type:Journal Article
- Keywords: Epilepsy,temporal lobe; Mitogen-activated protein kinases; Phosphorylation
- From: Chinese Journal of Neurology 2005;0(10):-
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate expression of extracelluar signal regulated protein kinase(ERK)and phosphorylation ERK(p-ERK)in the temporal lobe from patients with DR-TLE so as to explore the possible roles of ERK in the pathogenesis of DR-TLE.Methods Expression of ERK was detected with Western blot and immunohistochemistry in 32 patients with DR-TLE(24 temporal lobe,8 hippocampi),as compared with 12 controls(9 temporal lobe,3 hippocampi).Results ERK and p-ERK expression in DR-TLE was significantly higher(0.2266?0.0613,0.2097?0.0183 and 0.1924?0.0054,respectively)than those of controls(0.1840?0.0023,0.1974?0.0056 and 0.1825?0.0063,respectively,all P