Effect of Aire on the production of CD4~+CD25~+ regulatory T cells
- VernacularTitle:自身免疫调节因子(Aire)对CD4~+CD25~+调节性T细胞产生的影响
- Author:
Shijie SUN
;
Kangsheng LI
;
Matsumoto MITSURU
;
Yi LI
- Publication Type:Journal Article
- Keywords:
Autoimmune regulator;
CD4~+CD25~+ regulatory T cells;
Foxp3;
Peripheral tolerance
- From:
Chinese Journal of Immunology
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To clarify the role of Aire on the production of regulatory T cells on mice.Methods:The distribution of CD4~+CD25~+T cells and the expression of Foxp3 mRNA from Aire~ -/- thymus and spleen were separately analyzed using FACS and real-time PCR.Results:Compared with control mice, the total numbers of thymocytes/splenocytes and T cells from Aire~ -/- mice did not show any significant changes; The total CD4~+CD25~+ regulatory T-cell number and Foxp3 mRNA expression did not exhibit any statistically difference; The ratios of CD4~+CD25~+T cells out of CD4~+T cells were similar based on adult /day3/day7 mice analysis.Conclusion:Aire gene does not affect the production of CD4~+CD25~+ regulatory T cells.
