Expressions of Clara cell secretory protein (CC16) mRNA and protein in senile rats
- VernacularTitle:老年大鼠Clara细胞的分泌蛋白CC16 mRNA及CC16蛋白表达
- Author:
Chunhua CHI
;
Bing HE
;
Xiuying TANG
;
Xiangyan LI
- Publication Type:Journal Article
- Keywords:
Aging;
Lung;
Rats,Wister;
Epithelial cell;
Gene expression
- From:
Chinese Journal of Geriatrics
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expressions of Clara cell secretary protein (CC16) mRNA and protein in senile rats. Methods The histological changes, the level of CC16 mRNA in lung tissue and CC16 protein in terminal bronchioles and respiratory bronchioles were measured in 10 senile rats (at the age of 26 months) and compared with 7 young rats (aged 3 months). Results The epithelial cells lined up irregularly in respiratory bronchioles and mild emphysema were found in the senile group. Compared with young group,the level of CC16 mRNA was decreased[(0.08v1.71) vs (10. 02?4. 66) , P
