Meta-analysis of Genetic Polymorphisms of Glutathione S-transferase M1, T1 and Susceptibility to Childhood Acute Leukemia
- VernacularTitle:谷胱甘肽S-转移酶M1、T1基因多态性与儿童急性白血病遗传易感性的Meta分析
- Author:
Xujun ZHANG
;
Jie MIN
- Publication Type:Journal Article
- Keywords:
Leukemia, mixed-cell;
Child;
Gene;
Glutathione transferase;
Meta-analysis
- From:
Journal of Environment and Health
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To estimate the relationship of genetic polymorphisms of glutathione s-transferase M1, T1 (GSTM1 and GSTT1) and the susceptibility to childhood acute leukemia. Methods Meta-analysis was employed to estimate the relationship of genetic polymorphisms of GSTM1, GSTT1 and childhood acute leukemia based on relevant epidemiological papers published at home and abroad. Random effect model and fixed effect model analysis were used to calculate the incorporated odds ratio (ORc) based on homogeneity test. Results The ORc and 95% confidence interval for childhood acute leukemia associated with GSTM1 null and GSTT1 null was 1.31(95%CI: 1.01～1.71), 0.98(95%CI: 0.82～1.17) respectively. Conclusion GSTM1 null may be an important host risk factor for childhood acute leukemia, whereas GSTT1 null does not show a significant relationship with the risk to childhood acute leukemia.
