HLA-DRB1 binding CⅡ263-272 peptide inhibits collagen-induced arthritis
- VernacularTitle:HLA-DRB1结合性Ⅱ型胶原多肽抑制胶原性关节炎的实验研究
- Author:
Zhongqiang YAO
;
Ru LI
;
Zhanguo LI
- Publication Type:Journal Article
- Keywords:
Collagen-induced arthritis;
Altered peptide;
Collagen type Ⅱ;
Bone destruction
- From:
Chinese Journal of Immunology
2000;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the inhibition of collagen-induced arthritis by an altered CⅡ263-272 peptide(sub268-270) with three consecutive substitutions of TCR-contacting residues.Methods:Arthritis was induced by bovine collagen type Ⅱ. The altered peptide sub268-270 was given intravenously with a dose of 90 ?g once a week. Peptide control and blank control were treated with similar approaches. The therapeutic effect of the altered peptide was evaluated by arthritis score index, radiological score and pathological score.Results:The arthritis score of rats treated with altered peptide, control peptide and blank control were 5.60?1.24, 11.20?1.21 and 11.80?1.22 respectively(P
