The effect and the significance of the matrix metalloproteinases in the pathological changes of the rat experimental allergic encephalomyelitis
- VernacularTitle:基质金属蛋白酶在实验性变态反应性脑脊髓炎病理改变中的作用及意义
- Author:
Mei DONG
;
Ruichun LIU
;
Li GUO
;
Chunyan LI
- Publication Type:Journal Article
- Keywords:
Experimental allergic encephalomyelitis;
Matrix metalloproteinases;
Pathology;
Pathogenesis
- From:
Chinese Journal of Immunology
2000;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate pathological changes and the expression of the matrix metalloproteinases in rat EAE.Methods:The pathological changes of EAE were studied in Wistar rat with the aid of light and electron microscope and the expression and distribution of MMP-2,MMP-9 in different tissues were detected with the method of immunohistochemistry.Results:Light microscopy showed inflammatory cuff around small blood vessels were evident, disintegration and disappear of myelin sheath were observed. Electron microscopy showed a lot of loose and fragmental spiremes of myelin sheath, the component of axons and nissl bodies in neurons were disappeared. MMP-2,-9 were expressed intensively in vascular endothelial cells, meninges and accumulative inflammatory cells.Conclusion:MMPs take the roles in every aspect of the pathological changes in EAE, it can destroy the blood brain-barrier, degrade the myeline sheath, damage the axons and generate immunogens.
