The Value of Measurement of Fractional Anisotropy on the Splenium of the Corpus Callosum in Diagnosis of Patients with Mild Alzheimer’s Disease
- VernacularTitle:胼胝体压部FA值在轻度Alzheimer病中的诊断价值
- Author:
Sheng XIE
;
Hongkun WU
;
Jiangxi XIAO
;
Yinhua WANG
;
Xuexiang JIANG
- Publication Type:Journal Article
- Keywords:
MRI;
diffusion tensor imaging;
anisotropy;
Alzheimer’s disease
- From:
Journal of Practical Radiology
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect abnormal anisotropy on the splenium of the corpus callosum in patients with mild Alzheimer’s disease (AD).Methods Normalized hippocampal volume and fractional anisotropy on the splenium of the corpus callosum were measured in 13 patients with mild Alzheimer’s disease and 19 normally aging volunteers. Non-dependent samples t-tests were conducted to compare them between the two groups. In addition, the sensitivity in the diagnosis of mild Alzheimer’s disease was calculated.Results The splenium of the corpus callosum showed reduced anisotropy in mild Alzheimer’s disease. The normalized hippocampal volume also decreased in patients. The FA of the splenium of the corpus callosum was more sensitive in the diagnosis of mild Alzheimer’s disease. Conclusion The decreased anisotropy on the splenium of the corpus callosum reflects the degeneration of the fibers, and it is promising in the early diagnosis of Alzheimer’s disease.
