The effect on liver function after kidney transplantation of HBV carriers: comparison between tacrolimus and cyclosporin A
- VernacularTitle:乙型肝炎病毒携带者肾移植后应用他克莫司和环孢素A对肝功能影响的比较
- Author:
Guodong CHEN
;
Lizhong CHEN
;
Changxi WANG
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Hepatitis B;
Tacrolimus;
Cyclosporine
- From:
Chinese Journal of Organ Transplantation
2005;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of tacrolimus vs cyclosporin A on liver function after kidney transplantation. Methods Seventy-three cases of HBV carriers received kidney transplantation. Their liver functions before operation were normal and HBV DNA was negative. After operation they were divided into two groups: FK506 group (n=40) taking FK506, mycofenolate mofetil (MMF) and prednisone to prevent rejection. CsA group (n=33) taking CsA, MMF and prednisone to prevent rejection. The cases were followed for 1 to 6 years. The incidence of liver function admage and HBV DNA positive rate were observed in two groups. When damage to liver function appeared, the doses of immunosuppresive drugs were regulated, and the drugs protecting liver function were given. Results Four cases ( 10.0 % ) in FK506 group and 16 cases ( 48.5 %) in CsA group suffered the damage to liver function. In 2 cases ( 5.0 %) of FK506 group and 9 cases ( 27.3 %) of CsA group, HBV-DNA transferred to positive (P
