The study of the relationship between nuclear factor-?B(NF-?B) and P-glycoprotein(P-gp) on K562/A02 cells
- VernacularTitle:K562/A02细胞株核因子-?B活性与P糖蛋白的表达
- Author:
Haitao ZHANG
;
Yi WANG
;
Min YU
;
Xin LIU
- Publication Type:Journal Article
- Keywords:
K562/A02;
nuclear factor-?B;
P-glycoprotein
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between nuclear factor-?B(NF-?B) and(P-glycoprotein)((P-gp)) on K562/A02 cells.Methods NF-?B and P-gp of K562/A02 cells cultured with PDTC in different concentrations and time were detected by immunohisochemisty,and the relationship between them was analyzed.Results In K562/A02 cells,the expression of NF-?B and P-gp were positively correlated,and were concentration-dependent and the time dependent.Conclusion The mechanism of NF-?B regulating anti-apoptosis of K562/A02 cells is related with MDR1.
