Intervention of renal connective tissue growth factor expression and renal fibrosis by Benazepril:an experimental study in unilateral ureteral obstruction rats
- VernacularTitle:苯那普利对单侧输尿管梗阻大鼠肾脏结缔组织生长因子表达的影响
- Author:
Ganglian YAO
;
Ning NING
;
Dengfeng GAO
;
Baosong GUI
- Publication Type:Journal Article
- Keywords:
Benazepril;
fibrosis;
unilateral ureteral obstruction;
renal interstitium;
connective tissue growth factor
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of Benazepril on the renal connective tissue growth factor(CTGF) expression and interstitial fibrosis in unilateral ureteral obstruction(UUO) rats and to illuminate the possible mechanisms.Methods 24 Sprague-Dawley rats were randomly divided into Sham-operated,control and Benazepril groups.From the day before operation,the rats were under intragastric administration of Benazepril 10mg/(kg?d) in Benazepril group,and sodium chloride in tales doses in Sham and control groups.On the 14~(th) day after operation,the obstructed kidney was taken out to be measured by HE,Masson,and immunohistochemistry staining for TGF-?_1,CTGF,?-SMA and ColⅢ.Results The score of renal interstitial lesion and fibrosis index in Benazenpril were significantly lower than those in the control group(P
