Adrenoceptor and endothelin receptors of artery isolated from colonic cancer
- VernacularTitle:结肠癌血管的肾上腺素受体和内皮素受体
- Author:
Guangyu QI
;
Jie LI
;
Lin YANG
;
Hao LIU
;
Jing LIU
- Publication Type:Journal Article
- Keywords:
colonic cancer;
artery;
?-adrenoceptor;
ET_(A)receptor;
ET_(B) receptor
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the contraction of artery in colonic cancer.Methods Arteries in the cancer part and the cancer ambient part of patients with colonic cancer,the concentration-contractile curves induced by the noradrenaline(NA),sarafotoxin 6c(S6c) and endothelin-1(ET-1) in cumulative application were recorded by myograph.Results The E_(max) and pD_(2)of normal colonic artery contraction induced by NA were(97?19)% and(5.94)?0.17.The E_(max)and pD_(2) of contraction in colonic cancer artery was lower than that in cancer ambient artery(P0.05)).Conclusion The ?-adrenoceptor and ET_(A) receptor are main receptors mediating contraction in colonic cancer artery.
