Leptin level and its role in the regulation of reproductive function in females with anorexia nervosa
- VernacularTitle:女性神经性厌食症患者的瘦素水平及其在生殖功能调节中的作用
- Author:
Yongju ZHAO
;
Jieli LU
;
Jinfeng TANG
;
Jianming LIU
;
Shouyue SUN
;
Jie HONG
;
Shu WANG
;
Guang NING
- Publication Type:Journal Article
- Keywords:
Anorexia nervosa;
Leptin;
Reproductive function;
Female;
Amenorrhea
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between serum leptin level and the hypothalamuspituitary-gonad ( HPG) axis in female adolescents with anorexia nervosa ( AN). Methods Sixteen newly diagnosed female adolescents with AN in Shanghai and Zhejiang province were investigated, and their serum leptin, FSH, LH and body composition were measured before and after 18 weeks treatment, and their menorrhea cycles were observed. The rhythm of 24 h serum leptin secretion was studied in 4 patients with AN. Twenty-six, healthy females with normal weight and without contraceptive medication were studied as controls. Results (1) All of 16 patients had amenorrhea, 3 primary amenorrhea and 13 secondary amenorrhea. At admission LH in 14 patients and FSH in 12 patients were below the low limit of the normal reference range (1.5 U/L and 4. 6 U/L respectively), and among them 5 patiend had both 15% weight gain and significantly increased serum leptin level (P
