Insulin sensitivity and first-phase insulin secretion in obese subjects with impaired glucose regulation in Shanghai
- VernacularTitle:上海地区肥胖糖调节受损者的胰岛素敏感性和1相胰岛素分泌功能研究
- Author:
Jie HONG
;
Weiqiong GU
;
Yifei ZHANG
;
Yisheng YANG
;
Chunfang SHEN
;
Minghui GUI
;
Weiqing WANG
;
Yongju ZHAO
;
Guang NING
- Publication Type:Journal Article
- Keywords:
Impaired glucose regulation;
Impaired glucose tolerance;
Impaired fasting glucose;
Insulin resistance;
Acute insulin response
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study insulin sensitivity and first-phase insulin secretion in obese subjects with impaired glucose regulation (ICR) in Shanghai. Methods A total of 129 subjects [38 lean controls and 91 obese subjects with ICR including 64 isolated impaired glucose tolerance (IGT) ,8 isolated impaired fasting glucose (IFC) and 19 IFC + ICT] underwent 75 g oral glucose tolerance test and insulin-modified reduced sample number (n = 12) of Bergman's minimal model method with frequently sampled intravenous glucose tolerance test (FSIGTT). Insulin resistance was determined from the insulin sensitivity index (S1) of the FSIGTT. Insulin secretion was determined during the FSIGTT by the acute insulin response to glucose (AIRg). The disposition index (DI) , the product of AIRg and S1, was used to determine whether AIRg was adequate to compensate for insulin resistance. Results (1) Compared with normal controls, the value of S1 was significantly decreased in 3 groups with ICR (all P
