Effect of excessive iodine intake on bone metabolism in male rats
- VernacularTitle:碘过量摄入对雄性大鼠骨代谢的影响
- Author:
Naiping HUANG
;
Shunlu YU
;
Li WANG
- Publication Type:Journal Article
- Keywords:
Bone density;
Bone histomorphometry;
Potassium iodide;
Rats, Wistar;
Iodine excess
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore possible poisonous and harmful effect of excessive iodine intake on skeleton in male rats. Methods Male rat models receiving various amounts of excessive iodine were established for 3,6, 12 months, and quantitative bone histomorphometric parameters and bone mineral density (BMD) of femur and lumbar spine( L1-1 ) were measured by means of dual-energy X-ray absorptimetry in vitro, and rats receiving normal diet were considered as control group. Results There was no significant difference in bone mineral quantity and structural parameters after feeding excessive iodine for 3 months in comparison with control group. The BMD of L1-4 was significantly increased in all animal groups when various amounts of excessive iodide was taken for 6 months (all P
