A role of sodium selenite in regulating expression of cyclooxygenase-2 in rat mesangial cells
- VernacularTitle:亚硒酸钠对大鼠肾小球系膜细胞表达环氧化酶2的影响
- Author:
Qianping WEI
;
Huacong DENG
;
Jie ZHAO
- Publication Type:Journal Article
- Keywords:
Sodium selenite;
Cyclooxygenase-2;
Diabetic nephropathies;
Mesangial cells
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The expression of cyclooxygenase-2 (COX-2) mRNA and protein was significantly increased in rat glomerular mesangial cells (RCMC) treated separately with high glucose, high insulin, H2 O2 and advanced glycosylation end products. The expressions of COX-2 mRNA and protein in RCMC induced by above 4 factors were distinctly inhibited by sodium selenite, suggesting that sodium selenite might play a significant role in the prevention of diabetic nephropathy via this mechanism.
