The expression of heat shock 27 000 associated protein 1 in the brains of drug-refractory epilepsy
- VernacularTitle:耐药性癫癎患者脑组织中热休克蛋白27相关蛋白1的表达
- Author:
Jijun SUN
;
Lifeng GUAN
;
Xuefeng WANG
;
Zhiqin XI
;
Jinmei LI
;
Yun GONG
;
Fengying LIU
;
Yuan WU
;
Hui YANG
;
Jianguo ZHANG
;
Yuping WANG
;
Yunlin LI
;
Yong LU
;
Hongwei LI
- Publication Type:Journal Article
- Keywords:
Epilepsy;
Carrier proteins;
Nerve tissue proteins;
Apoptosis;
Mossy fibers, hippocampal
- From:
Chinese Journal of Neurology
2005;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of heat shock 27 000 associated protein 1 ( HSPBAP1, GenBank: AK096705) in the brain tissues of patients with drug-refractory epilepsy and discuss its function in the pathogenesis. Methods Fluorescent quantitative polymerase chain reaction ( FQ-PCR) and immunohistochemistry were used to test the expression of HSPBAP1 in the surgically removed brain tissues of patients with drug-refractory epilepsy from the brain bank of our department ( n = 36) , and the results were compared with that of normal controls (n = 8 ). Results The relative expression of HSPBAP1 mRNA in the brains of patients with drug-refractory epilepsy was more than 34. 11 times that of controls, and HSPBAP1 protein expression was significantly increased in temporal lobe cortex (0. 0507?0. 0003, P
